The Shallow Seas Coaprovel

- certain antipsychotics (for example, thioridazine, chlorpromazine, levomepromazine, triflurazine, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol);

Film-coated tablets, 12.5 mg + 150 mg (manufactured by Sanofi Winthrop Industry, Tours, France): 28 tab. in blister made of PVC / PVDC / Al. 1 bl. placed in a cardboard box.

Violations of the water-electrolyte balance and metabolic disorders. Thiazides, including hydrochlorothiazide, can cause imbalance water-electrolyte (hypokalemia, hyponatremia and hypochloremic alkalosis). Although the use of thiazide diuretics in monotherapy, especially in high doses, the development of hypokalemia is possible, the concomitant administration of irbesartan can reduce the hypokalemia caused by hydrochlorothiazide. On the contrary, due to irbesartan, which is part of the Coaprovel ® preparation, hyperkalemia can occur, especially in the presence of renal failure, heart failure, and diabetes mellitus. Regular monitoring of potassium serum in patients at risk is recommended..

For more information about treatment with CoAprovel, read the leaflet package (also part of the EPAR) or contact your doctor or pharmacist.

Treatment of essential hypertension. This fixed dose combination is indicated in patients whose blood pressure is not adequately controlled on irbesartan or hydrochlorothiazide alone.

Hydrochlorothiazide can potentiate the effects of non-depolarizing muscle relaxants (e.g., tubocurarine), local anesthetics, general anesthetics, and sedation agents before general anesthesia, which may require correction of their dosing regimen. When combined with hydrochlorothiazide, local anesthesia, general anesthesia and sedation before general anesthesia should be used in reduced doses. If possible, hydrochlorothiazide should be discontinued 1 week before surgery.

Irbesartan and its metabolites are excreted both through the intestines (with bile) and the kidneys. After oral or intravenous administration of 14 C-irbesartan, 20% of the radioactivity is found in the urine, and the rest in the feces. Less than 2% of the dose is excreted by the kidneys in the form of unchanged irbesartan. The final T 1/2 of irbesartan is 11-15 hours. The total clearance of intravenously administered irbesartan is 157-176 ml / min, and its renal clearance is 3-3.5 ml / min..

Important information about the organic ingredients of CoAprovel CoAprovel contém lactose. For informational purposes, please contact us at the following address: http://www.lactose.com/index.html.

Os medicamentos não devem ser eliminados na canalização or no lixo doméstico. Pergunt ao seu farmacêutico como eliminar os medicamentos que já não necessita. Estas medidas irão ajudar to protect o ambiente.

No one can realizado estudios sobre the capacidad para conducir y utilizar máquinas. It is likely that CoAprovel modifies the capacidad para conducir vehículos o utilizar máquinas. Sin embargo, durante el tratamiento of hipertensión pueden aparecer ocasionalmente mareos o fatiga. If you are interested in medical medications, please contact us.

Tenga especial cuidado con CoAprovel Informe a medico in cualquiera de los siguientes casos: if tiene vómitos o diarrea excesivos if padece alteraciones del riñón o tiene a trasplante de riñón if padece alteraciones del corazón if padece alteraciones del hígado if padece diabetes si padece lupus eritematoso (también conocido como lupus o LES) if the primo aldosteronismo padece (una condición relacionada con the elevated producción of the hormona aldosterona, lo que provoca retención de sodio y, su su vez, an aumento of the arterial presión).

There is a lot of good luck in combating the main principles of the game, and we can not exclude the opponent's adversaries as well. Efectos adversos asociados únicamente con irbesartan Además de los efectos adversos descritos anteriormente, también se ha observado dolor en el pecho.

Irbesartan on its own has been approved in the European Union (EU) since 1997 under the names Karvea and Aprovel. It can be used with hydrochlorothiazide to treat hypertension. The studies of Karvea / Aprovel used with hydrochlorothiazide as separate tablets were used to support the use of CoAprovel. Further studies were conducted with doses of 300 mg irbesartan in combination with 25 mg hydrochlorothiazide. The measure of effectiveness in the diastolic blood pressure (the blood pressure measured between two heartbeats).

Hypersensitive (allergic) to irbesartan, hydrochlorothiazide, sulfonamides, or any of the other ingredients. It should not be used in women who are more than three months pregnant. It is not recommended. CoAprovel must also be used in patients who have severe liver problems, high blood potassium levels or high calcium levels that are too high.

CoAprovel was more effective than placebo (a dummy treatment) and only hydrochlorothiazide alone in reducing diastolic blood pressure. Increasing the dose to 300 mg irbesartan and 25 mg hydrochlorothiazide may give a further decrease in blood pressure.

Hepatic impairment: Thiazides should be used with caution in patients with hepatic insufficiency or progressive liver disease because even mild changes in fluid and electrolyte balance may be impaired. There is no data available. clinics available with CoAprovel in patients with hepatic impairment.

Important Notice: The International Drugs.com database is in BETA release. This means it is still under development and may contain inaccuracies. It is a substitute for the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to be appropriate or appropriate for you. Consult with your healthcare professional.

Additional information on hydrochlorothiazide interactions: When concurrently, the following medicinal products may interact with thiazide diuretics:

When necessary, CoAprovel may be administered with another antihypertensive medicinal product (see sections 4.3, 4.4, 4.5 and 5.1).

Irbesartan had no effect on fertility of treated rats and their offspring up to the dose levels of parental toxicity (see section 5.3).

Rare cases of allergic skin reactions (rash, urticaria), reported in patients taking irbesartan.